Npgrj_Nn_1949 1..3
نویسندگان
چکیده
Fever is a result of the action of prostaglandin E2 (PGE2) on the brain and appears to require EP3 prostaglandin receptors (EP3Rs), but the specific neurons on which PGE2 acts to produce fever have not been definitively established. Here we report that selective genetic deletion of the EP3Rs in the median preoptic nucleus of mice resulted in abrogation of the fever response. These observations demonstrate that the EP3Rbearing neurons in the median preoptic nucleus are required for fever responses.
منابع مشابه
Comportamento da criança
" ( %+#+& $ (* 1$*$ $#2( ,-$" (" /3+% $ 1$* $% +*(4 $ 3+ 1%,+45+ +$ "(% "/#*( ,3+ + -,3($4+"$6+%,4'$&+%,4'$"1$ ,+ 7 ( + (6,1,841,+ 3+ %$ ,4+ +3$ +3+ (&$" +/ $%(" +%+ "/+ %(+&,9+5:$ 7 ( 3("1%(-(% + %$ ,4+ 3$ (;+*(< 1$4 %,#/,43$ +%+ "/+ *(& $% (;(1/5:$ $% $/ %$" %$6,"",$4+," 3+ =%(+ *>3,1+! %$" (1 ,-$ 1&?4,1$ %+43$*,9+3$ ! !" %("(4 ( (" /3$ 6$, %(+&,9+3$ 1$* 1%,+45+" ( +3$&("1(4 ("< 1/2+ 6+,;+ ( ...
متن کاملThe Illusion of Certainty
"BC53(3#3*1!=*?3B;!-1:8!/@/1!<*./!(*8!-BC53(3#3*1!=.-B#3B/!#*:-;!=./(5</(!#A-#! B/.#-31#;!3(!Y/;!#*!(5BB/((8!-1:!#A-#!51B/.#-31#;!*.!:/?-;(!31!-BA3/@312!B/.#-31#;!./2-.:312! 5(/.!1//:(!*.!(*?5#3*1!-==.*-BA!,3??!1/B/((-.3?;!3<=/:/!=.*2./((D!ZA3(!</-1(!#A-#!,A/1! 51B/.#-31#;!-.3(/(!:5.312!-1!-BC53(3#3*1!/++*.#8!#A/!1-#5.-?!./(=*1(/!3(!#*!<-Y/!:/B3(3*1(!#A-#! ./(*?@/!#A3(!51B/.#-31#;D!&1B/.#-31#3/...
متن کاملEin Modell zum begründungsbasierten Freigabemanagement
.;3+?',#! K,;M#<+-! ;3+#%! 3'$/! '-! -;3+?',#! -J-+#C-! ',#! <;CK/#_! '%1! <*'%)#! 3,#b2#%+/J@! D;! K#,3;,C! K,;M#<+-! ?$+*! <*'%)#-! -2<<#--32//J9! ')$/#! /$3#! <J</#! C;1#/-!K,;K;-#!-*;,+!,#/#'-#!<J</#-9!;3+#%!/'-+$%)!;%/J!3#?!?##(-@!F*#,#'-! ,#/#'-#!C'%')#C#%+!*'-!3;<2-#1!;%!+*#!1#/$5#,J!;3!+*#!-J-+#C!'+!+*#!#%1!;3!'! K,;M#<+!2K!+;!%;?9!%;?!$+! $-! +2,%$%)! $%!'!K,;M#<+! 32%<+$;%!'<<;CK'%J$%...
متن کاملImproving the Efficiency of a Multicast File Transfer Tool based on ALC
Sequential transmission of 3 objects layer_3 layer_2 layer_1 layer_0 (4 symbols/tick) (2 symbols/tick) (1 symbol/tick) (1 symbol/tick) time transm. layer t0 t7 t1t2 t6 t3 obj_1 object_2 object_1 object_1 object_1 object_3 object_3 obj_2 obj_3 object_2 object_3 object_2 t5 t4 Ô 1 1 3 2 2 2 3 3 2 2 2 3 3 3 2 3 1 2 3 3 2 3 1 1 1 1 1 2 2 1 1 1 2 3 1 3 1 2 1 3 1 3 3 2 1 2 layer_3 layer_2 layer_1 lay...
متن کامل(Mart\355nez Mendoza, S. \(2007\)...)
7 ! +, %.3, , 8 5 1 & , 93 3 1 : 1 , . , , . , ;; + 3 1 : / 93 . 1 . / ! < %.3, 93 , . , 8 . / . 3 , , . ;01, . ; , . / 5 / . ' , = 1 > : , . , 8. . > , 3 . /, , . , .. , & ' 1 8 . . , . ' , 1: > , 3 3 ,% 1 : 93 1 , . 3 . . / 8. . . % > , ., = , , 93 . . & , %.3, > 93 5 . 8, 3 , .. / 3. 93 , 93 . , . . / , . ;01, . !! < %.3, 93 . 3 / , . , . , . 01, . > 3 2, , . , 8. . 3 . / , . . .. . 3 . . / ...
متن کامل